Baby 2 · IVF · Repromeda Biology Park, Brno

Repromeda — Cycle 1

Cycles: Cycle 1 (done — 3 oocytes) · Cycle 2 (projected)
Cycle 1 protocol & medications

Short antagonist protocol. Two drugs grow the eggs (stimulation); three control when they release (one blocks early ovulation, two trigger it on schedule). All five prescribed by Dr. Filková on May 26.

Medication Role Dose When
Stimulation — grow the eggs
Gonal-F Pure FSH 250 IU / day From CD2; adjusted by monitoring
Pergoveris FSH 150 + LH 75 150 IU / day From CD2; same time each morning
Ovulation control & trigger — time the release
Cetrotide Antagonist (blocks early ovulation) 0.25 mg / day Added CD8 (Jun 8), daily until trigger
Diphereline Agonist trigger 0.1 mg Fri Jun 12, 8:30 pm sharp (~36 h before retrieval)
Ovitrelle hCG trigger 250 mcg Fri Jun 12, 8:30 pm, with Diphereline

Diphereline + Ovitrelle together = dual trigger (two hormones to mature more eggs, lower OHSS risk). Stim dose finalized at Gonal-F 250 IU on the May 28 invoice (down from 300 IU on the original prescription).

EST. Estimated event

Mon
25
CD24
Tue
26
CD25
Wed
27
CD26
Thu
28
CD27
Fri
29
CD28
Sat
30
CD29
Sun
31
CD0
Mon 25
First Visit — Brno
  • AFC 4, AMH 0.9
  • Protocol set
  • 1,500 EUR paid
Tue 26
Wed 27
Protocol confirmed
  • Prescriptions (5 meds)
  • Hormonal profile results
  • Stim CD2–3, 1st US CD6–7, retrieval CD12–14
  • PANDA + karyotype: 4–6 weeks
Thu 28
Meds invoice paid · protocol finalized
  • Gonal-F 250 IU + Pergoveris 150 IU from CD2
  • No testosterone priming (levels normal)
  • Invoice €1,206 paid · DHL shipped
Fri 29
Meds arrive (DHL)
  • 1× Pergoveris 900 IU
  • 2× Gonal-F 900 IU
Sat 30
Sun 31
Period started (eve) · Cycle Day 0
  • Onset after 16:00 → clinic counts as CD0
  • Mon Jun 1 = CD1
Mon
1
CD1
Tue
2
CD2
Wed
3
CD3
Thu
4
CD4
Fri
5
CD5
Sat
6
CD6
Sun
7
CD7
Mon 1
Tue 2
Stimulation starts
  • Each morning, same time daily
Gonal-F 250 Pergoveris 150
Wed 3
Gonal-F 250 Pergoveris 150
Thu 4
Gonal-F 250 Pergoveris 150
Fri 5
Gonal-F 250 Pergoveris 150
Sat 6
1st ultrasound — Brno (done)
  • Low response. Left: 2 follicles — 10 mm, 12 mm. Right: minimal — one ~5 mm
  • Possibly 2–3 eggs this cycle
  • Plan: stims unchanged through Tue; add Cetrotide Mon + Tue; US#2 Tue
Gonal-F 250 Pergoveris 150
Sun 7
Stims continue · watching right ovary
  • No trigger yet — giving the smaller follicles more time to grow
Gonal-F 250 Pergoveris 150
Mon
8
CD8
Tue
9
CD9
Wed
10
CD10
Thu
11
CD11
Fri
12
CD12
Sat
13
CD13
Sun
14
CD14
Mon 8
Cetrotide starts · ECG (HU)
  • Antagonist added to block early ovulation
  • ECG 8:30–9:30 am via MIL's friend — free, <10 min
Gonal-F 250 Pergoveris 150 Cetrotide 0.25
Tue 9
2nd ultrasound — Brno (done)
  • Left growing well: 2 follicles — 15 mm + 15 mm. Right: one 8 mm — borderline (Dr. Filková)
  • Plan: let them grow more → US#3 Thu; retrieval pushed to Sat/Sun
  • EndomeTRIO (all-inclusive package) discussed — worth doing for age profile
Gonal-F 250 Pergoveris 150 Cetrotide 0.25
Wed 10
Stims continue · letting follicles grow
Gonal-F 250 Pergoveris 150 Cetrotide 0.25
Thu 11
3rd ultrasound — Brno (done)
  • More follicles visible. Left: 17 mm + 15 mm, plus 2 more (10, 8). Right: one 11 mm
  • Plan: one more stim day Fri → trigger Fri 8:30 pm → retrieval Sun 9 am
  • Met Victoria — HU-speaking coordinator, super helpful; HU pharmacy/prescription info via Adam
Gonal-F 250 Pergoveris 150 Cetrotide 0.25
Fri 12
Last stim day · dual trigger 8:30 pm
  • Diphereline 0.1 + Ovitrelle 250 at exactly 8:30 pm (~36 h before retrieval)
  • Diphereline prep (per Adéla): mix the 2 liquids + 2 powders with the thick needle, inject with the thin one. Ovitrelle comes pre-prepared
  • No injections after trigger
  • Adam: 1–2 day abstinence before the sample is ideal — no longer, no shorter (Adéla)
  • Package decision due to Adéla today — All-Inclusive vs Spermpacket options
  • Emotionally very fragile all day — after the evening shots, a big, long, ugly cry.
Gonal-F 250 Pergoveris 150 Cetrotide 0.25
Sat 13
Travel to Brno · overnight stay
  • Hotel booked: Courtyard by Marriott Brno (conf 87653047) — check-in 3 pm, check-out Sun 12 pm
  • Holandska 12 · parking 450 CZK/day · 2,102 CZK total
  • Rest day — no injections
Sun 14
Egg retrieval — Brno (done)
  • 3 oocytes retrieved under general anesthesia — in line with the ~2–3 forecast
  • Smooth, alert recovery; minimal discomfort. Progesterone tablets started (evenings)
  • Cycle 2 planned: short protocol again, same meds + doses, Androgel priming; scripts in Hungary
Cumulative costs

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